The traditional and a new version of the mouse H-2 complex

Jan Klein, Antonio Juretí, Constantin N. Baxevanis, Zoltan A. Nagy

Research output: Contribution to journalArticlepeer-review

223 Scopus citations


The H-2 complex has traditionally been interpreted as a maze of regions, subregions and loci coding for different traits. The two main theses presented here are, first, that a single H-2 locus is pleiomorphic in that it controls several functions such as allograft rejection, cell-mediated lymphocytotoxicity, mixed lymphocyte reaction, immune response, immune suppression and restriction of T-cell specificity; and second, that the physiological f unction of the H-2 complex is to guide T lymphocytes in theirfunction of distinguishing self from non-self, and that all other H-2-controlled traits are artificial derivatives of this basic function. These two theses lead to a new, simplified interpretation of the H-2 complex.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
Issue number5815
StatePublished - 1981

All Science Journal Classification (ASJC) codes

  • General


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