TY - JOUR
T1 - The unique chemistry of benzoxaboroles
T2 - Current and emerging applications in biotechnology and therapeutic treatments
AU - Liu, C. Tony
AU - Tomsho, John W.
AU - Benkovic, Stephen J.
N1 - Funding Information:
C.T.L. would like to acknowledge postdoctoral fellowships from The Natural Sciences and Engineering Research Council of Canada .
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8/15
Y1 - 2014/8/15
N2 - Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.
AB - Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.
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U2 - 10.1016/j.bmc.2014.04.065
DO - 10.1016/j.bmc.2014.04.065
M3 - Review article
C2 - 24864040
AN - SCOPUS:84906262239
SN - 0968-0896
VL - 22
SP - 4462
EP - 4473
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 16
ER -