TY - JOUR
T1 - The Use of Biomarkers After Inflicted Traumatic Brain Injury
T2 - Insight into Etiology, Pathophysiology, and Biochemistry
AU - Berger, Rachel Pardes
AU - Hymel, Kent
AU - Gao, Wei Min
N1 - Funding Information:
This study was supported in part by NIH 1K23HD43843-01 (RB), NIH 1R21HD043351-03 (KH), CDC R49/CCR323155-01 (RB) General Clinical Research Center, Children's Hospital of Pittsburgh Grant #M01 RR00084 (RB).
PY - 2006/9
Y1 - 2006/9
N2 - Inflicted traumatic brain injury (iTBI) is the most common cause of severe brain injury in infants. Proper diagnosis is difficult even for experienced emergency department physicians. Misdiagnosis is common and can have catastrophic consequences for patients and society. After iTBI, biochemical markers are released from brain tissue and pass into the cerebrospinal fluid and serum. Measuring the concentrations of these markers may help to identify brain injury that could otherwise be missed. Biomarkers may also be able to help differentiate noninflicted TBI from iTBI, assist in the timing of iTBI, improve our understanding of the pathophysiology of iTBI, and predict outcome after iTBI.
AB - Inflicted traumatic brain injury (iTBI) is the most common cause of severe brain injury in infants. Proper diagnosis is difficult even for experienced emergency department physicians. Misdiagnosis is common and can have catastrophic consequences for patients and society. After iTBI, biochemical markers are released from brain tissue and pass into the cerebrospinal fluid and serum. Measuring the concentrations of these markers may help to identify brain injury that could otherwise be missed. Biomarkers may also be able to help differentiate noninflicted TBI from iTBI, assist in the timing of iTBI, improve our understanding of the pathophysiology of iTBI, and predict outcome after iTBI.
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U2 - 10.1016/j.cpem.2006.06.001
DO - 10.1016/j.cpem.2006.06.001
M3 - Article
AN - SCOPUS:33750615512
SN - 1522-8401
VL - 7
SP - 186
EP - 193
JO - Clinical Pediatric Emergency Medicine
JF - Clinical Pediatric Emergency Medicine
IS - 3
ER -