The use of ct densitometry to predict lung toxicity in bone marrow transplant patients

Ellen E. El-Khatib, Carolyn R. Freeman, Witold B. Rybka, Shirley Lehnert, Ervin B. Podgorsak

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Total body irradiation (TBI) is considered an integral part of the preparation of patients with hematological malignancies for marrow transplantation. One of the major causes of death following bone marrow transplantation is interstitial pneumonia. Its pathogenesis is complex but radiation may play a major role in its development. Computed tomography (CT) has been used in animal and human studies as a sensitive non-invasive method for detecting changes in the lung following radiotherapy. In the present study CT scans are studied before and up to 1 year after TBI. Average lung densities measured before TBI showed large variations among the individual patients. On follow-up scans, lung density decreases were measured for patients who did not develop lung complications. Significant lung density increases were measured in patients who subsequently had lung complications. These lung density increases were observed prior to the onset of respiratory complications and could be correlated with the clinical course of the patients, suggesting the possibility for the usage of CT lung densitometry to predict lung complications before the onset of clinical symptoms.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalInternational Journal of Radiation Oncology, Biology, Physics
Issue number1
StatePublished - Jan 1989

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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