TY - JOUR
T1 - The YYRR box
T2 - A conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes
AU - Cavener, Douglas
AU - Feng, Yue
AU - Foster, Brian
AU - Krasney, Philip
AU - Murtha, Michael
AU - Schonbaum, Christopher
AU - Xiao, Xiao
PY - 1988/4/25
Y1 - 1988/4/25
N2 - We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronlc location.
AB - We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronlc location.
UR - http://www.scopus.com/inward/record.url?scp=0024296645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024296645&partnerID=8YFLogxK
U2 - 10.1093/nar/16.8.3375
DO - 10.1093/nar/16.8.3375
M3 - Article
C2 - 3375058
AN - SCOPUS:0024296645
SN - 0305-1048
VL - 16
SP - 3375
EP - 3390
JO - Nucleic acids research
JF - Nucleic acids research
IS - 8
ER -