Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors

Elena Sineva, Maria Savkina, Sarah E. Ades

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


The ECF sigma family was identified 23 years ago as a distinct group of σ70-like factors. ECF sigma factors have since emerged as a major form of bacterial signal transduction that can be grouped into over 50 phylogenetically distinct subfamilies. Advances in our understanding of these sigma factors and the signaling pathways governing their activity have elucidated conserved features as well as aspects that have evolved over time. All ECF sigma factors are predicted to share a common streamlined domain structure and mode of promoter interaction. The activity of most ECF sigma factors is controlled by an anti-sigma factor. The nature of the anti-sigma factor and the activating signaling pathways appear to be conserved within ECF families, while considerable diversity exists between different families.

Original languageEnglish (US)
Pages (from-to)128-137
Number of pages10
JournalCurrent Opinion in Microbiology
StatePublished - Apr 2017

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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