Theory of host-microbe symbioses: Challenges and opportunities

Pamela Ferretti; Maria M. Martignoni; Lisa C. McManus; Taom Sakal; Armun Liaghat; Bethany Stevens; Kyle J.M. Dahlin; Lucas S. Souza; Zoe G. Cardon; Cynthia B. Silveira; Seth R. Bordenstein; Joan Roughgarden

doi:10.1016/j.chom.2025.05.001

Theory of host-microbe symbioses: Challenges and opportunities

Pamela Ferretti
, Maria M. Martignoni
, Lisa C. McManus
, Taom Sakal
, Armun Liaghat
, Bethany Stevens
, Kyle J.M. Dahlin
, Lucas S. Souza
, Zoe G. Cardon
, Cynthia B. Silveira
, Seth R. Bordenstein
, Joan Roughgarden

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Growing insight into microbial symbioses highlights the need to model these systems mathematically. We discuss three areas requiring theoretical advancement: nested ecology within a host or holobiont, holobiont population dynamics, and symbiont-mediated speciation. Developing the proposed frameworks will bridge theory and empirical findings, accelerating our understanding of host-microbe symbioses.

Original language	English (US)
Pages (from-to)	1052-1056
Number of pages	5
Journal	Cell Host and Microbe
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.chom.2025.05.001
State	Published - Jul 9 2025

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Virology

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10.1016/j.chom.2025.05.001

Cite this

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title = "Theory of host-microbe symbioses: Challenges and opportunities",

abstract = "Growing insight into microbial symbioses highlights the need to model these systems mathematically. We discuss three areas requiring theoretical advancement: nested ecology within a host or holobiont, holobiont population dynamics, and symbiont-mediated speciation. Developing the proposed frameworks will bridge theory and empirical findings, accelerating our understanding of host-microbe symbioses.",

author = "Pamela Ferretti and Martignoni, \{Maria M.\} and McManus, \{Lisa C.\} and Taom Sakal and Armun Liaghat and Bethany Stevens and Dahlin, \{Kyle J.M.\} and Souza, \{Lucas S.\} and Cardon, \{Zoe G.\} and Silveira, \{Cynthia B.\} and Bordenstein, \{Seth R.\} and Joan Roughgarden",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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language = "English (US)",

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TY - JOUR

T1 - Theory of host-microbe symbioses

T2 - Challenges and opportunities

AU - Ferretti, Pamela

AU - Martignoni, Maria M.

AU - McManus, Lisa C.

AU - Sakal, Taom

AU - Liaghat, Armun

AU - Stevens, Bethany

AU - Dahlin, Kyle J.M.

AU - Souza, Lucas S.

AU - Cardon, Zoe G.

AU - Silveira, Cynthia B.

AU - Bordenstein, Seth R.

AU - Roughgarden, Joan

PY - 2025/7/9

Y1 - 2025/7/9

N2 - Growing insight into microbial symbioses highlights the need to model these systems mathematically. We discuss three areas requiring theoretical advancement: nested ecology within a host or holobiont, holobiont population dynamics, and symbiont-mediated speciation. Developing the proposed frameworks will bridge theory and empirical findings, accelerating our understanding of host-microbe symbioses.

AB - Growing insight into microbial symbioses highlights the need to model these systems mathematically. We discuss three areas requiring theoretical advancement: nested ecology within a host or holobiont, holobiont population dynamics, and symbiont-mediated speciation. Developing the proposed frameworks will bridge theory and empirical findings, accelerating our understanding of host-microbe symbioses.

UR - https://www.scopus.com/pages/publications/105009508039

UR - https://www.scopus.com/pages/publications/105009508039#tab=citedBy

U2 - 10.1016/j.chom.2025.05.001

DO - 10.1016/j.chom.2025.05.001

M3 - Comment/debate

C2 - 40639335

AN - SCOPUS:105009508039

SN - 1931-3128

VL - 33

SP - 1052

EP - 1056

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 7

ER -

Theory of host-microbe symbioses: Challenges and opportunities

Abstract

All Science Journal Classification (ASJC) codes

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