@article{b542142e15924d16a2aa1100881c3f77,
title = "Therapeutic Systems and Technologies: State-of-the-Art Applications, Opportunities, and Challenges",
abstract = "In this review, we present current state-of-the-art developments and challenges in the areas of thermal therapy, ultrasound tomography, image-guided therapies, ocular drug delivery, and robotic devices in neurorehabilitation. Additionally, intellectual property and regulatory aspects pertaining to therapeutic systems and technologies are addressed.",
author = "Mohamed Almekkawy and Vesna Zderic and Jie Chen and Ellis, {Michael D.} and Dieter Haemmerich and Holmes, {David R.} and Linte, {Cristian A.} and Dorin Panescu and John Pearce and Punit Prakash",
note = "Funding Information: Manuscript received September 1, 2018; revised December 9, 2018; accepted March 21, 2019. Date of publication April 2, 2019; date of current version January 20, 2020. This work was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under Award No. R35GM128877 and in part by the Office of Advanced Cyber Infrastructure of the National Science Foundation under Award No. 1808530. (Corresponding author: Jie Chen.) M. Almekkawy is with the Pennsylvania State University, University Park, PA 16802 USA (e-mail:,mka9@psu.edu). J. Chen is with the University of Alberta, Edmonton, AB T6G 2R3, Canada (e-mail:,jchen@ece.ualberta.ca). M. D. Ellis is with the Northwestern University, Evanston, IL 60208 USA (e-mail:,m-ellis@northwestern.edu). D. Haemmerich is with the University of South Carolina, Columbia, SC 29208 USA (e-mail:,dhaemme@clemson.edu). D. R. Holmes, III is with the Mayo Clinic, Rochester, MN 55905 USA (e-mail:,Holmes.David3@mayo.edu). C. A. Linte is with the Rochester Institute of Technology, Rochester, NY 14623 USA (e-mail:,calbme@rit.edu). D. Panescu is with the HeartBeam, Inc., Santa Clara, CA 95050-2525 USA (e-mail:,panescu_d@yahoo.com). J. Pearce is with the University of Texas at Austin, Austin, TX 78712 USA (e-mail:,jpearce@mail.utexas.edu). P. Prakash is with the Kansas State University, Manhattan, KS 66506 USA (e-mail:,prakashp@ksu.edu). V. Zderic is with the George Washington University, Washington, DC 20052 USA (e-mail:,zderic@gwu.edu). Digital Object Identifier 10.1109/RBME.2019.2908940 Publisher Copyright: {\textcopyright} 2008-2011 IEEE.",
year = "2020",
doi = "10.1109/RBME.2019.2908940",
language = "English (US)",
volume = "13",
pages = "325--339",
journal = "IEEE Reviews in Biomedical Engineering",
issn = "1937-3333",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
}