Therapy for chronic hepatitis B: The earlier, the better?

Jianming Hu; David Nguyen

doi:10.1016/j.tim.2004.08.007

Therapy for chronic hepatitis B: The earlier, the better?

Jianming Hu, David Nguyen

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.

Original language	English (US)
Pages (from-to)	431-433
Number of pages	3
Journal	Trends in Microbiology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/j.tim.2004.08.007
State	Published - Oct 2004

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2004.08.007

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title = "Therapy for chronic hepatitis B: The earlier, the better?",

abstract = "It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.",

author = "Jianming Hu and David Nguyen",

year = "2004",

month = oct,

doi = "10.1016/j.tim.2004.08.007",

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T1 - Therapy for chronic hepatitis B

T2 - The earlier, the better?

AU - Hu, Jianming

AU - Nguyen, David

PY - 2004/10

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N2 - It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.

AB - It has been recently reported that uninfected hepatocytes that repopulate the liver following clearance of a chronic hepatitis B virus infection are derived from previously infected cells. As these cells accumulate genetic damage over the course of infection, the risk of liver cancer arising from this damage might not be eliminated by viral clearance. Therefore, initiation of antiviral therapy early in the course of infection to prevent the accumulation of this damage is proposed to be the best course of action.

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DO - 10.1016/j.tim.2004.08.007

M3 - Short survey

C2 - 15381188

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EP - 433

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 10

ER -

Therapy for chronic hepatitis B: The earlier, the better?

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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