TY - JOUR
T1 - Therapy-related myelodysplastic syndrome with inv(16)(p13q22) and I type CBFβ/MYH11 after autologous transplantation
T2 - Undetectable fusion transcript in pretransplant progenitor cells
AU - Yamamoto, Katsuya
AU - Nishikawa, Shinichiro
AU - Minagawa, Kentaro
AU - Yakushijin, Kimikazu
AU - Okamura, Atsuo
AU - Matsui, Toshimitsu
N1 - Funding Information:
This work was supported in part by grants-in-aid for scientific research from the Ministry of Health, Welfare and Labor and from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Nos. 17590997 and 17790643).
PY - 2006/3
Y1 - 2006/3
N2 - We describe here a unique case of therapy-related myelodysplastic syndrome (t-MDS) with inv(16)(p13q22) after autologous stem cell transplantation for lymphoma. The rare and smallest I type CBFβ/MYH11 fusion transcript with a breakpoint at nucleotide 399 of CBFβ and at nucleotide 2134 of MYH11 was detected in the bone marrow cells by reverse transcription polymerase chain reaction analysis. However, the fusion transcript was undetectable in the pretransplant peripheral blood stem cells. These results suggest that the stem cell damage leading to t-MDS may be induced mainly by the conditioning regimen for transplantation. Taken together with previous reports, the I type fusion transcript is preferentially induced with chemotherapy.
AB - We describe here a unique case of therapy-related myelodysplastic syndrome (t-MDS) with inv(16)(p13q22) after autologous stem cell transplantation for lymphoma. The rare and smallest I type CBFβ/MYH11 fusion transcript with a breakpoint at nucleotide 399 of CBFβ and at nucleotide 2134 of MYH11 was detected in the bone marrow cells by reverse transcription polymerase chain reaction analysis. However, the fusion transcript was undetectable in the pretransplant peripheral blood stem cells. These results suggest that the stem cell damage leading to t-MDS may be induced mainly by the conditioning regimen for transplantation. Taken together with previous reports, the I type fusion transcript is preferentially induced with chemotherapy.
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U2 - 10.1016/j.leukres.2005.08.001
DO - 10.1016/j.leukres.2005.08.001
M3 - Article
C2 - 16165210
AN - SCOPUS:30144439910
SN - 0145-2126
VL - 30
SP - 354
EP - 361
JO - Leukemia Research
JF - Leukemia Research
IS - 3
ER -
