Thiazides and calcium stones: Overrated or underused?

John Knoedler, Amy E. Krambeck

Research output: Chapter in Book/Report/Conference proceedingChapter


The lifetime incidence of urolithiasis is approximately 10-15∈% in the USA, with calcium-containing stones the most common offender. Among recurrent stone formers, thiazide-type diuretics have traditionally represented first-line therapy for prevention of recurrent calcium stones. However, with improved understanding of the benefits of lifestyle modification and alternative therapies for stone prevention, the utility of thiazides as first-line agents has recently come into question. This chapter will explore the rational for thiazide usage in the prevention of recurrent calcium stone disease, evaluate the evidence in favor of and against thiazides as first-line therapy, and finally examine the cost-effective use of thiazides and their comparative effectiveness to alternative forms of treatment.

Original languageEnglish (US)
Title of host publicationPractical Controversies in Medical Management of Stone Disease
PublisherSpringer New York
Number of pages11
ISBN (Electronic)9781461495758
ISBN (Print)1461495741, 9781461495741
StatePublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • General Medicine


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