Think globally, act locally: Centrosome-localized mRNAs ensure mitotic ﬁdelity

Daniela C. Zarnescu

doi:10.1083/JCB.202010172

Think globally, act locally: Centrosome-localized mRNAs ensure mitotic ﬁdelity

Daniela C. Zarnescu

Research output: Contribution to journal › Article › peer-review

Abstract

The functional importance of mRNA localization to centrosomes is unclear. Ryder et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202004101) identify fragile-X mental retardation protein as a regulator of centrocortin (cen) mRNA dynamics in Drosophila. Mistargeting of cen impairs division and development, indicating that cen mRNA localization to centrosomes ensures mitotic ﬁdelity.

Original language	English (US)
Article number	e202010172
Journal	Journal of Cell Biology
Volume	219
Issue number	12
DOIs	https://doi.org/10.1083/JCB.202010172
State	Published - Dec 7 2020

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1083/JCB.202010172

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title = "Think globally, act locally: Centrosome-localized mRNAs ensure mitotic ﬁdelity",

abstract = "The functional importance of mRNA localization to centrosomes is unclear. Ryder et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202004101) identify fragile-X mental retardation protein as a regulator of centrocortin (cen) mRNA dynamics in Drosophila. Mistargeting of cen impairs division and development, indicating that cen mRNA localization to centrosomes ensures mitotic ﬁdelity.",

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AB - The functional importance of mRNA localization to centrosomes is unclear. Ryder et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202004101) identify fragile-X mental retardation protein as a regulator of centrocortin (cen) mRNA dynamics in Drosophila. Mistargeting of cen impairs division and development, indicating that cen mRNA localization to centrosomes ensures mitotic ﬁdelity.

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Think globally, act locally: Centrosome-localized mRNAs ensure mitotic ﬁdelity

Abstract

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