Threading your way to protein function

Steven M. Firestine; Andrew E. Nixon; Stephen J. Benkovic

doi:10.1016/S1074-5521(96)90061-7

Threading your way to protein function

Steven M. Firestine, Andrew E. Nixon, Stephen J. Benkovic

Chemistry

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.

Original language	English (US)
Pages (from-to)	779-783
Number of pages	5
Journal	Chemistry and Biology
Volume	3
Issue number	10
DOIs	https://doi.org/10.1016/S1074-5521(96)90061-7
State	Published - 1996

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(96)90061-7

Cite this

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title = "Threading your way to protein function",

abstract = "It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.",

author = "Firestine, {Steven M.} and Nixon, {Andrew E.} and Benkovic, {Stephen J.}",

note = "Funding Information: The authors w&Id like to thank the Damon Runyon-Walter Winchell Foundation (S.M.F.) and the National Institutes of Health (GMl3306, A.E.N. and S.J.B.) for funding.",

year = "1996",

doi = "10.1016/S1074-5521(96)90061-7",

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issn = "1074-5521",

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T1 - Threading your way to protein function

AU - Firestine, Steven M.

AU - Nixon, Andrew E.

AU - Benkovic, Stephen J.

N1 - Funding Information: The authors w&Id like to thank the Damon Runyon-Walter Winchell Foundation (S.M.F.) and the National Institutes of Health (GMl3306, A.E.N. and S.J.B.) for funding.

PY - 1996

Y1 - 1996

N2 - It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.

AB - It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.

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U2 - 10.1016/S1074-5521(96)90061-7

DO - 10.1016/S1074-5521(96)90061-7

M3 - Comment/debate

C2 - 8939694

AN - SCOPUS:0030253252

SN - 1074-5521

VL - 3

SP - 779

EP - 783

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 10

ER -

Threading your way to protein function

Abstract

All Science Journal Classification (ASJC) codes

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