Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency

Robert Murphy, Shadi Kordbacheh, Dimitrios Skoulas, Simon Ng, Kasinan Suthiwanich, Andrea M. Kasko, Sally Ann Cryan, Deirdre Fitzgerald-Hughes, Ali Khademhosseini, Amir Sheikhi, Andreas Heise

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Through rational design, block sequence controlled triblock copolypeptides comprising cysteine and tyrosine as well as a lysine or glutamic acid central block are devised. In these copolypeptides, each block contributes a specific property to the hydrogels to render them extrusion printable and antimicrobial. Three-dimensional (3D) printing of complex hydrogel structures with high shape retention is demonstrated. Moreover, composition dependent potent antimicrobial activity in contact-killing assays is elucidated.

Original languageEnglish (US)
Pages (from-to)5144-5149
Number of pages6
JournalBiomaterials Science
Volume9
Issue number15
DOIs
StatePublished - Aug 7 2021

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • General Materials Science

Fingerprint

Dive into the research topics of 'Three-dimensionally printable shear-thinning triblock copolypeptide hydrogels with antimicrobial potency'. Together they form a unique fingerprint.

Cite this