Tic disorders and ADHD: Answers from a world-wide clinical dataset on Tourette syndrome

Roger D. Freeman; Henrik Aabech; Javad Allaghband-Rad; Cheston Berlin; Ruth Bruun; Cathy Budman; Larry Burd; Francesco Cardona; Francisco Cardoso; Jose Castillo; Susan Chien; Sylvain Chouinard; Yves Dion; Jacques Eisenberg; Nihal Erfan; Diane Fast; John Fayyed; Emilio Fernandez-Alvarez; Ken Gadow; Oscar Gershanik; Michel Gil; Don Gilbert; Helga Hannesdottir; Don Higgins; Piotr Janik; Joseph Jankovic; Bjorn Kadesjo; Yukiko Kano; Jacob Kerbeshian; Abraham Kessler; U. Finn Knudsen; Anne Korsgaard; Anthony Lang; David Lichter; Trygve Lindback; Zhisheng Liu; Danielle Lobel; Alida Magor; Euripides Miguel; Kirsten Mueller-Vahl; Kieran O'Connor; Jessica Oesterheld; Larry Pancer; Hugh Rickards; Mary Robertson; Veit Roessner; Aribert Rothenberger; Jeffrey Rubin; Evzen Ruzicka; Kim St. John; Paul Sandor; Anton Scamvougeras; Gary Shady; Miriam Spinner; Mara Stamenkovic; Jeffrey Sverd; Zsanett Tarnok; Chris Van Der Linden; Arja Voutilainen; Yanki Yazgan; Zheng Yi; Sam Zinner

doi:10.1007/s00787-007-1003-7

Tic disorders and ADHD: Answers from a world-wide clinical dataset on Tourette syndrome

Roger D. Freeman, Henrik Aabech, Javad Allaghband-Rad, Cheston Berlin, Ruth Bruun, Cathy Budman, Larry Burd, Francesco Cardona, Francisco Cardoso, Jose Castillo, Susan Chien, Sylvain Chouinard, Yves Dion, Jacques Eisenberg, Nihal Erfan, Diane Fast, John Fayyed, Emilio Fernandez-Alvarez, Ken Gadow, Oscar GershanikMichel Gil, Don Gilbert, Helga Hannesdottir, Don Higgins, Piotr Janik, Joseph Jankovic, Bjorn Kadesjo, Yukiko Kano, Jacob Kerbeshian, Abraham Kessler, U. Finn Knudsen, Anne Korsgaard, Anthony Lang, David Lichter, Trygve Lindback, Zhisheng Liu, Danielle Lobel, Alida Magor, Euripides Miguel, Kirsten Mueller-Vahl, Kieran O'Connor, Jessica Oesterheld, Larry Pancer, Hugh Rickards, Mary Robertson, Veit Roessner, Aribert Rothenberger, Jeffrey Rubin, Evzen Ruzicka, Kim St. John, Paul Sandor, Anton Scamvougeras, Gary Shady, Miriam Spinner, Mara Stamenkovic, Jeffrey Sverd, Zsanett Tarnok, Chris Van Der Linden, Arja Voutilainen, Yanki Yazgan, Zheng Yi, Sam Zinner

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Abstract

Background: Tourette syndrome (TS) is a neurodevelopmental disorder with frequent comorbidity with Attention- deficit-Hyperactivity disorder (ADHD). The impact of this association is still a matter of debate. Method: Using the TIC database containing 6,805 cases, the clinical differences were ascertained between subjects with and without ADHD. Results: The reported prevalence of ADHD in TS was 55%, within the range of many other reports. If the proband was diagnosed with ADHD, a family history of ADHD was much more likely. ADHD was associated with earlier diagnosis of TS and a much higher rate of anger control problems, sleep problems, specific learning disability, OCD, Oppositional-defiant disorder, mood disorder, social skill deficits, sexually inappropriate behaviour, and self-injurious behaviour. Subjects with seizures and with Developmental Coordination Disorder also had high rates of ADHD. Anxiety disorder, however, was not more frequent. Preliminary data suggest that most behavioural difficulties in ADHD are associated with the Combined or Hyperactive-Impulsive Subtypes of ADHD. Every large site (>200 cases) had a significantly increased rate of anger control problems in cases with ADHD. Conclusion: Subjects with TS have high rates of ADHD and complex associations with other disorders. Clinically the findings confirm other research indicating the importance of ADHD in understanding the behavioural problems often associated with the diagnosis of TS. Additional ADHD comorbidity should be taken into account in diagnosis, management, and training.

Original language	English (US)
Pages (from-to)	I/15-I/23
Journal	European Child and Adolescent Psychiatry
Volume	16
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s00787-007-1003-7
State	Published - Jul 2007

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Developmental and Educational Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00787-007-1003-7

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Freeman, R. D., Aabech, H., Allaghband-Rad, J., Berlin, C., Bruun, R., Budman, C., Burd, L., Cardona, F., Cardoso, F., Castillo, J., Chien, S., Chouinard, S., Dion, Y., Eisenberg, J., Erfan, N., Fast, D., Fayyed, J., Fernandez-Alvarez, E., Gadow, K., ... Zinner, S. (2007). Tic disorders and ADHD: Answers from a world-wide clinical dataset on Tourette syndrome. European Child and Adolescent Psychiatry, 16(SUPPL. 1), I/15-I/23. https://doi.org/10.1007/s00787-007-1003-7

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title = "Tic disorders and ADHD: Answers from a world-wide clinical dataset on Tourette syndrome",

abstract = "Background: Tourette syndrome (TS) is a neurodevelopmental disorder with frequent comorbidity with Attention- deficit-Hyperactivity disorder (ADHD). The impact of this association is still a matter of debate. Method: Using the TIC database containing 6,805 cases, the clinical differences were ascertained between subjects with and without ADHD. Results: The reported prevalence of ADHD in TS was 55%, within the range of many other reports. If the proband was diagnosed with ADHD, a family history of ADHD was much more likely. ADHD was associated with earlier diagnosis of TS and a much higher rate of anger control problems, sleep problems, specific learning disability, OCD, Oppositional-defiant disorder, mood disorder, social skill deficits, sexually inappropriate behaviour, and self-injurious behaviour. Subjects with seizures and with Developmental Coordination Disorder also had high rates of ADHD. Anxiety disorder, however, was not more frequent. Preliminary data suggest that most behavioural difficulties in ADHD are associated with the Combined or Hyperactive-Impulsive Subtypes of ADHD. Every large site (>200 cases) had a significantly increased rate of anger control problems in cases with ADHD. Conclusion: Subjects with TS have high rates of ADHD and complex associations with other disorders. Clinically the findings confirm other research indicating the importance of ADHD in understanding the behavioural problems often associated with the diagnosis of TS. Additional ADHD comorbidity should be taken into account in diagnosis, management, and training.",

author = "Freeman, {Roger D.} and Henrik Aabech and Javad Allaghband-Rad and Cheston Berlin and Ruth Bruun and Cathy Budman and Larry Burd and Francesco Cardona and Francisco Cardoso and Jose Castillo and Susan Chien and Sylvain Chouinard and Yves Dion and Jacques Eisenberg and Nihal Erfan and Diane Fast and John Fayyed and Emilio Fernandez-Alvarez and Ken Gadow and Oscar Gershanik and Michel Gil and Don Gilbert and Helga Hannesdottir and Don Higgins and Piotr Janik and Joseph Jankovic and Bjorn Kadesjo and Yukiko Kano and Jacob Kerbeshian and Abraham Kessler and Knudsen, {U. Finn} and Anne Korsgaard and Anthony Lang and David Lichter and Trygve Lindback and Zhisheng Liu and Danielle Lobel and Alida Magor and Euripides Miguel and Kirsten Mueller-Vahl and Kieran O'Connor and Jessica Oesterheld and Larry Pancer and Hugh Rickards and Mary Robertson and Veit Roessner and Aribert Rothenberger and Jeffrey Rubin and Evzen Ruzicka and {St. John}, Kim and Paul Sandor and Anton Scamvougeras and Gary Shady and Miriam Spinner and Mara Stamenkovic and Jeffrey Sverd and Zsanett Tarnok and {Van Der Linden}, Chris and Arja Voutilainen and Yanki Yazgan and Zheng Yi and Sam Zinner",

year = "2007",

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doi = "10.1007/s00787-007-1003-7",

language = "English (US)",

volume = "16",

pages = "I/15--I/23",

journal = "European Child and Adolescent Psychiatry",

issn = "1018-8827",

publisher = "D. Steinkopff-Verlag",

number = "SUPPL. 1",

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Freeman, RD, Aabech, H, Allaghband-Rad, J, Berlin, C, Bruun, R, Budman, C, Burd, L, Cardona, F, Cardoso, F, Castillo, J, Chien, S, Chouinard, S, Dion, Y, Eisenberg, J, Erfan, N, Fast, D, Fayyed, J, Fernandez-Alvarez, E, Gadow, K, Gershanik, O, Gil, M, Gilbert, D, Hannesdottir, H, Higgins, D, Janik, P, Jankovic, J, Kadesjo, B, Kano, Y, Kerbeshian, J, Kessler, A, Knudsen, UF, Korsgaard, A, Lang, A, Lichter, D, Lindback, T, Liu, Z, Lobel, D, Magor, A, Miguel, E, Mueller-Vahl, K, O'Connor, K, Oesterheld, J, Pancer, L, Rickards, H, Robertson, M, Roessner, V, Rothenberger, A, Rubin, J, Ruzicka, E, St. John, K, Sandor, P, Scamvougeras, A, Shady, G, Spinner, M, Stamenkovic, M, Sverd, J, Tarnok, Z, Van Der Linden, C, Voutilainen, A, Yazgan, Y, Yi, Z & Zinner, S 2007, 'Tic disorders and ADHD: Answers from a world-wide clinical dataset on Tourette syndrome', European Child and Adolescent Psychiatry, vol. 16, no. SUPPL. 1, pp. I/15-I/23. https://doi.org/10.1007/s00787-007-1003-7

TY - JOUR

T1 - Tic disorders and ADHD

T2 - Answers from a world-wide clinical dataset on Tourette syndrome

AU - Freeman, Roger D.

AU - Aabech, Henrik

AU - Allaghband-Rad, Javad

AU - Berlin, Cheston

AU - Bruun, Ruth

AU - Budman, Cathy

AU - Burd, Larry

AU - Cardona, Francesco

AU - Cardoso, Francisco

AU - Castillo, Jose

AU - Chien, Susan

AU - Chouinard, Sylvain

AU - Dion, Yves

AU - Eisenberg, Jacques

AU - Erfan, Nihal

AU - Fast, Diane

AU - Fayyed, John

AU - Fernandez-Alvarez, Emilio

AU - Gadow, Ken

AU - Gershanik, Oscar

AU - Gil, Michel

AU - Gilbert, Don

AU - Hannesdottir, Helga

AU - Higgins, Don

AU - Janik, Piotr

AU - Jankovic, Joseph

AU - Kadesjo, Bjorn

AU - Kano, Yukiko

AU - Kerbeshian, Jacob

AU - Kessler, Abraham

AU - Knudsen, U. Finn

AU - Korsgaard, Anne

AU - Lang, Anthony

AU - Lichter, David

AU - Lindback, Trygve

AU - Liu, Zhisheng

AU - Lobel, Danielle

AU - Magor, Alida

AU - Miguel, Euripides

AU - Mueller-Vahl, Kirsten

AU - O'Connor, Kieran

AU - Oesterheld, Jessica

AU - Pancer, Larry

AU - Rickards, Hugh

AU - Robertson, Mary

AU - Roessner, Veit

AU - Rothenberger, Aribert

AU - Rubin, Jeffrey

AU - Ruzicka, Evzen

AU - St. John, Kim

AU - Sandor, Paul

AU - Scamvougeras, Anton

AU - Shady, Gary

AU - Spinner, Miriam

AU - Stamenkovic, Mara

AU - Sverd, Jeffrey

AU - Tarnok, Zsanett

AU - Van Der Linden, Chris

AU - Voutilainen, Arja

AU - Yazgan, Yanki

AU - Yi, Zheng

AU - Zinner, Sam

PY - 2007/7

Y1 - 2007/7

N2 - Background: Tourette syndrome (TS) is a neurodevelopmental disorder with frequent comorbidity with Attention- deficit-Hyperactivity disorder (ADHD). The impact of this association is still a matter of debate. Method: Using the TIC database containing 6,805 cases, the clinical differences were ascertained between subjects with and without ADHD. Results: The reported prevalence of ADHD in TS was 55%, within the range of many other reports. If the proband was diagnosed with ADHD, a family history of ADHD was much more likely. ADHD was associated with earlier diagnosis of TS and a much higher rate of anger control problems, sleep problems, specific learning disability, OCD, Oppositional-defiant disorder, mood disorder, social skill deficits, sexually inappropriate behaviour, and self-injurious behaviour. Subjects with seizures and with Developmental Coordination Disorder also had high rates of ADHD. Anxiety disorder, however, was not more frequent. Preliminary data suggest that most behavioural difficulties in ADHD are associated with the Combined or Hyperactive-Impulsive Subtypes of ADHD. Every large site (>200 cases) had a significantly increased rate of anger control problems in cases with ADHD. Conclusion: Subjects with TS have high rates of ADHD and complex associations with other disorders. Clinically the findings confirm other research indicating the importance of ADHD in understanding the behavioural problems often associated with the diagnosis of TS. Additional ADHD comorbidity should be taken into account in diagnosis, management, and training.

AB - Background: Tourette syndrome (TS) is a neurodevelopmental disorder with frequent comorbidity with Attention- deficit-Hyperactivity disorder (ADHD). The impact of this association is still a matter of debate. Method: Using the TIC database containing 6,805 cases, the clinical differences were ascertained between subjects with and without ADHD. Results: The reported prevalence of ADHD in TS was 55%, within the range of many other reports. If the proband was diagnosed with ADHD, a family history of ADHD was much more likely. ADHD was associated with earlier diagnosis of TS and a much higher rate of anger control problems, sleep problems, specific learning disability, OCD, Oppositional-defiant disorder, mood disorder, social skill deficits, sexually inappropriate behaviour, and self-injurious behaviour. Subjects with seizures and with Developmental Coordination Disorder also had high rates of ADHD. Anxiety disorder, however, was not more frequent. Preliminary data suggest that most behavioural difficulties in ADHD are associated with the Combined or Hyperactive-Impulsive Subtypes of ADHD. Every large site (>200 cases) had a significantly increased rate of anger control problems in cases with ADHD. Conclusion: Subjects with TS have high rates of ADHD and complex associations with other disorders. Clinically the findings confirm other research indicating the importance of ADHD in understanding the behavioural problems often associated with the diagnosis of TS. Additional ADHD comorbidity should be taken into account in diagnosis, management, and training.

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VL - 16

SP - I/15-I/23

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

IS - SUPPL. 1

ER -

Tic disorders and ADHD: Answers from a world-wide clinical dataset on Tourette syndrome

Abstract

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