Time course of myocardial amiodarone uptake in the piglet heart using a chronic animal model

S. D. Beder, M. H. Cohen, G. BenShachar

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8 Scopus citations

Abstract

This investigation sought to study single dose pharmacokinetics of amiodarone in a chronic animal model. We developed a new chronic animal model that allows Serial direct access to the heart of the immature piglet via an implanted acrylic thoracic window. Following instrumentation and 72-hour recovery, amiodarone (5 mg/kg) was administered as a single intravenous bolus in immature piglets. Timed paired serum samples and myocardial biopsies for amiodarone level were obtained prior to, and up to 72 hours following, amiodarone administration. Peak concentrations of amiodarone in both serum (3.60 ± 1.02 μg/ml) and tissue (84.2 ± 6.50 ng/mg) occurred within 5 minutes of drug administration. As reported by others, this study demonstrated that the volume of distribution (V(D)) of amiodarone was large (33.31 ± 35.21 L/kg), and the clearance (Cl) was low (13.6 ± 4.4 ml/min/kg). Marked prolongation of both the serum t( 1/4 ) (29.98 ± 29.26 hours) and the myocardial t( 1/4 ) (29.20 ± 29.49 hours) were noted as well. The early, rapid myocardial peak of amiodarone in the immature myocardium corresponds with recent clinical observations of onset of antiarrhythmic efficacy 5 to 10 minutes following intravenous amiodarone administration in young children.

Original languageEnglish (US)
Pages (from-to)204-211
Number of pages8
JournalPediatric cardiology
Volume19
Issue number3
DOIs
StatePublished - May 1998

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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