Time-division multiplexed resistive pulse sensor on a microfluidic chip

Gihoon Choi, Erica Murphy, Weihua Guan

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Due to its simplicity and robustness, resistive pulse sensors have been widely used to detect, measure, and analyze particles at length scales ranging from nanometers to micrometers. While multiple pore-based resistive pulse sensors are preferred to increase the analysis throughput and to overcome the clogging issues, the scalability is often limited. Here we reported a microfluidic time-division multiplexing accessing (TDMA) single-end resistive pulse sensor, in which particles can be analyzed through a scalable number of microfluidic channels. This multiplexed approach is effective in measuring the particle size and concentration, in analyzing the particle arriving dynamics, and in discriminating mixed populations. It also provides a robust mechanism to overcome the clogging issue, allowing the analysis to continue even when some of the pores are clogged.

Original languageEnglish (US)
Title of host publication2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728116341
StatePublished - Oct 2019
Event18th IEEE Sensors, SENSORS 2019 - Montreal, Canada
Duration: Oct 27 2019Oct 30 2019

Publication series

NameProceedings of IEEE Sensors
ISSN (Print)1930-0395
ISSN (Electronic)2168-9229


Conference18th IEEE Sensors, SENSORS 2019

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering


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