TY - JOUR
T1 - TIMP-1 and its potential diagnostic and prognostic value in pulmonary diseases
AU - Almuntashiri, Sultan
AU - Alhumaid, Abdullah
AU - Zhu, Yin
AU - Han, Yohan
AU - Dutta, Saugata
AU - Khilji, Ohmed
AU - Zhang, Duo
AU - Wang, Xiaoyun
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/6
Y1 - 2023/6
N2 - Tissue inhibitors of metalloproteases (TIMPs) have caught the attention of many scientists due to their role in various physiological and pathological processes. TIMP-1, 2, 3, and 4 are known members of the TIMPs family. TIMPs exert their biological effects by, but are not limited to, inhibiting the activity of metalloproteases (MMPs). The balance between MMPs and TIMPs is critical for maintaining homeostasis of the extracellular matrix (ECM), while the imbalance between MMPs and TIMPs can lead to pathological changes, such as cancer. In this review, we summarized the current knowledge of TIMP-1 in several pulmonary diseases namely, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pneumonia, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and pulmonary fibrosis. Considering the potential of TIMP-1 serving as a non-invasive diagnostic and/or prognostic biomarker, we also reviewed the circulating TIMP-1 levels in translational and clinical studies.
AB - Tissue inhibitors of metalloproteases (TIMPs) have caught the attention of many scientists due to their role in various physiological and pathological processes. TIMP-1, 2, 3, and 4 are known members of the TIMPs family. TIMPs exert their biological effects by, but are not limited to, inhibiting the activity of metalloproteases (MMPs). The balance between MMPs and TIMPs is critical for maintaining homeostasis of the extracellular matrix (ECM), while the imbalance between MMPs and TIMPs can lead to pathological changes, such as cancer. In this review, we summarized the current knowledge of TIMP-1 in several pulmonary diseases namely, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pneumonia, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and pulmonary fibrosis. Considering the potential of TIMP-1 serving as a non-invasive diagnostic and/or prognostic biomarker, we also reviewed the circulating TIMP-1 levels in translational and clinical studies.
UR - https://www.scopus.com/pages/publications/85168496334
UR - https://www.scopus.com/pages/publications/85168496334#tab=citedBy
U2 - 10.1016/j.pccm.2023.05.002
DO - 10.1016/j.pccm.2023.05.002
M3 - Review article
C2 - 38343891
AN - SCOPUS:85168496334
SN - 2097-1982
VL - 1
SP - 67
EP - 76
JO - Chinese Medical Journal Pulmonary and Critical Care Medicine
JF - Chinese Medical Journal Pulmonary and Critical Care Medicine
IS - 2
ER -
