TY - JOUR
T1 - Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene
AU - Carrel, Laura
AU - Hunt, Patricia A.
AU - Willard, Huntington F.
N1 - Funding Information:
We thank C. Brown for helpful discussions and are grateful to K. Gustashaw, K. Mroz, and R. LeMaire for technical assistance. This work was supported by NIH research grants GM45441 (to HFW) and HD27393 (to PAH).
PY - 1996/9
Y1 - 1996/9
N2 - To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes. In all tissues assayed, Smcx only partially escapes X inactivation, with expression levels from the inactive X allele ~ 30-65% that of the active X allele. Additionally, inactive X expression levels differed between extraembryonic and embryonic tissues and among different tissues from newborn and adult mice. Imprinted extraembryonic tissue had the lowest levels of inactive X Smcx expression, whereas the highest levels were in heart. These data suggest that the chromosomal basis of X inactivation differs among tissues, perhaps reflecting differences in the timing or regulation of inactivation in these cell lineages.
AB - To understand how gene expression patterns are established on the inactive X chromosome during development, we have studied the murine gene Smcx, which is expressed from both the active and inactive mouse X chromosomes. In all tissues assayed, Smcx only partially escapes X inactivation, with expression levels from the inactive X allele ~ 30-65% that of the active X allele. Additionally, inactive X expression levels differed between extraembryonic and embryonic tissues and among different tissues from newborn and adult mice. Imprinted extraembryonic tissue had the lowest levels of inactive X Smcx expression, whereas the highest levels were in heart. These data suggest that the chromosomal basis of X inactivation differs among tissues, perhaps reflecting differences in the timing or regulation of inactivation in these cell lineages.
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U2 - 10.1093/hmg/5.9.1361
DO - 10.1093/hmg/5.9.1361
M3 - Article
C2 - 8872478
AN - SCOPUS:0029791177
SN - 0964-6906
VL - 5
SP - 1361
EP - 1366
JO - Human molecular genetics
JF - Human molecular genetics
IS - 9
ER -