TY - JOUR
T1 - Tissue production of androgens in women with acne
AU - Lookingbill, Donald P.
AU - Horton, Richard
AU - Demers, Laurence M.
AU - Egan, Nancy
AU - Marks, James G.
AU - Santen, Richard J.
N1 - Funding Information:
From the Department of Medicine (Divisions of Dermatology and Endocrinology) and the Department of Pathology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, and the Department of Medicine, Section of Endocri-nology, University of Southern California School of Medicine, Los Angeles. Supported in part by National Institutes of Health Grant No. AM13710 and the Core Endocrine Laboratory of The Milton S. Hershey Medical Center. Accepted for publication Sept. 27, 1984. Reprint requests to: Dr. Donald P. LookingbiU, Chief, Division of Dermatology, The Milton S. Hershey Medical Center, P.O. Box 850, Hershey, PA 17033.
PY - 1985
Y1 - 1985
N2 - Precursor and target tissue-produced androgens were measured in the plasma of eighteen women with mild to moderate acne. Mean plasma levels of the precursor androgens (total testosterone, free testosterone, androstenedione, and dehydroepiandrosterone sulfate) were similar to levels in a group of carefully selected acne-free and hirsute-free, age-matched female controls. In contrast, plasma 3α-androstanediol glucuronide (3α-diol G) values were elevated in 13 of the patients, with a mean value for the entire group nearly threefold that of the normal controls (117 vs 43 ng/dl; p < 0.001), These results support the concept that target tissue androgen production plays an important hormonal role in the pathogenesis of acne in women and that plasma 3α-diol G may be the most sensitive marker of this process.
AB - Precursor and target tissue-produced androgens were measured in the plasma of eighteen women with mild to moderate acne. Mean plasma levels of the precursor androgens (total testosterone, free testosterone, androstenedione, and dehydroepiandrosterone sulfate) were similar to levels in a group of carefully selected acne-free and hirsute-free, age-matched female controls. In contrast, plasma 3α-androstanediol glucuronide (3α-diol G) values were elevated in 13 of the patients, with a mean value for the entire group nearly threefold that of the normal controls (117 vs 43 ng/dl; p < 0.001), These results support the concept that target tissue androgen production plays an important hormonal role in the pathogenesis of acne in women and that plasma 3α-diol G may be the most sensitive marker of this process.
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U2 - 10.1016/S0190-9622(85)70067-9
DO - 10.1016/S0190-9622(85)70067-9
M3 - Article
C2 - 3157707
AN - SCOPUS:0021911820
SN - 0190-9622
VL - 12
SP - 481
EP - 487
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -