TLR-mediated cell signaling by malaria GPIs

D. Channe Gowda

    Research output: Contribution to journalReview articlepeer-review

    121 Scopus citations

    Abstract

    Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite-host factors involved in activating and regulating innate immune responses and of the associated signaling mechanisms is likely to provide insights into the modulation of parasite-specific adaptive immunity and offer targets for the development of novel therapeutics or a vaccine for malaria. This article focuses on the malaria GPI-mediated cell-signaling mechanisms.

    Original languageEnglish (US)
    Pages (from-to)596-604
    Number of pages9
    JournalTrends in Parasitology
    Volume23
    Issue number12
    DOIs
    StatePublished - Dec 2007

    All Science Journal Classification (ASJC) codes

    • Parasitology
    • Infectious Diseases

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