To protect and defend: Central nervous system prophylaxis in patients with non-Hodgkin's lymphoma

Hwee Yong Lim, Eckhard Thiel, Michael J. Glantz

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Purpose of review Despite remarkable advances in the treatment of non-Hodgkin's lymphoma of all histologie subtypes, nervous system involvement remains a dire complication associated with a rapid decline in quality of life, few good treatment options, and a short overall survival. In fact, these advances in treatment may be fueling an increase in the frequency of nervous system relapse. A better understanding of the epidemiology, diagnostic techniques, and options for prophylaxis of the central nervous system may be one of the best strategies for improving the outcome in patients with non-Hodgkin's lymphoma. Recent findings Central nervous system relapse in patients with non-Hodgkin's lymphoma is, typically, an early event, occurs in the setting of well described histologic, demographic, and clinical risk factors, and is characterized primarily by the involvement of the cerebrospinal fluid. Cerebrospinal fluid prophylaxis in high-risk patients appears to be effective in reducing the frequency of this complication. Summary More aggressive attention to diagnosis, focused on cytologie and flow cytometric evaluation of the cerebrospinal fluid in high-risk patients, will identify more patients with early and potentially more treatable central nervous system lymphoma. Cerebrospinal fluid prophylaxis appears to reduce the frequency of this complication in high-risk populations, but controversy remains regarding the most important high-risk characteristics and the optimum prophylactic interventions.

Original languageEnglish (US)
Pages (from-to)495-501
Number of pages7
JournalCurrent opinion in oncology
Issue number5
StatePublished - Sep 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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