To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

George Lucian Moldovan; Alan D. D'Andrea

doi:10.1016/j.ccr.2012.06.006

To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

George Lucian Moldovan, Alan D. D'Andrea

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

Original language	English (US)
Pages (from-to)	5-6
Number of pages	2
Journal	Cancer Cell
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2012.06.006
State	Published - Jul 10 2012

All Science Journal Classification (ASJC) codes

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2012.06.006

Cite this

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title = "To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks",

abstract = "DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.",

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AU - D'Andrea, Alan D.

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AB - DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

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To the Rescue: The Fanconi Anemia Genome Stability Pathway Salvages Replication Forks

Abstract

All Science Journal Classification (ASJC) codes

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