TY - JOUR
T1 - Tobacco smoking as a risk factor of bronchioloalveolar carcinoma of the lung
T2 - Pooled analysis of seven case-control studies in the International Lung Cancer Consortium (ILCCO)
AU - Boffetta, Paolo
AU - Jayaprakash, Vijayvel
AU - Yang, Ping
AU - Asomaning, Kofi
AU - Muscat, Joshua E.
AU - Schwartz, Ann G.
AU - Zhang, Zuo Feng
AU - Le Marchand, Loic
AU - Cote, Michele L.
AU - Stoddard, Shawn M.
AU - Morgenstern, Hal
AU - Hung, Rayjean J.
AU - Christiani, David C.
N1 - Funding Information:
Acknowledgments The original studies were supported by the following grants: WSU1 and WSU2 studies: NIH R01CA60691, R01CA87895, N01PC35145, and P30CA22453; HU study: NIH R01CA074386, R01CA092824, and P20CA090578; UCLA study: NIH R01DA11386 and R01CA90833; UH study: NIH R01CA55874; Mayo study: NIH-CA 77118, NIH-CA 80127, and NIH-CA 84354; AHF study: NIH CA-32617, CA-68384, CA-29580, and CA-17613.
PY - 2011/1
Y1 - 2011/1
N2 - Background: The International Lung Cancer Consortium (ILCCO) was established in 2004, based on the collaboration of research groups leading large molecular epidemiology studies of lung cancer that are ongoing or have been recently completed. This framework offered the opportunity to investigate the role of tobacco smoking in the development of bronchioloalveolar carcinoma (BAC), a rare form of lung cancer. Methods: Our pooled data comprised seven case-control studies from the United States, with detailed information on tobacco smoking and histology, which contributed 799 cases of BAC and 15,859 controls. We estimated the odds ratio of BAC for tobacco smoking, using never smokers as a referent category, after adjustment for age, sex, race, and study center. Results: The odds ratio of BAC for ever smoking was 2.47 (95% confidence interval [CI] 2.08, 2.93); the risk increased linearly with duration, amount, and cumulative cigarette smoking and persisted long after smoking cessation. The proportion of BAC cases attributable to smoking was 0.47 (95% CI 0.39, 0.54). Conclusions: This analysis provides a precise estimate of the risk of BAC for tobacco smoking.
AB - Background: The International Lung Cancer Consortium (ILCCO) was established in 2004, based on the collaboration of research groups leading large molecular epidemiology studies of lung cancer that are ongoing or have been recently completed. This framework offered the opportunity to investigate the role of tobacco smoking in the development of bronchioloalveolar carcinoma (BAC), a rare form of lung cancer. Methods: Our pooled data comprised seven case-control studies from the United States, with detailed information on tobacco smoking and histology, which contributed 799 cases of BAC and 15,859 controls. We estimated the odds ratio of BAC for tobacco smoking, using never smokers as a referent category, after adjustment for age, sex, race, and study center. Results: The odds ratio of BAC for ever smoking was 2.47 (95% confidence interval [CI] 2.08, 2.93); the risk increased linearly with duration, amount, and cumulative cigarette smoking and persisted long after smoking cessation. The proportion of BAC cases attributable to smoking was 0.47 (95% CI 0.39, 0.54). Conclusions: This analysis provides a precise estimate of the risk of BAC for tobacco smoking.
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U2 - 10.1007/s10552-010-9676-5
DO - 10.1007/s10552-010-9676-5
M3 - Article
C2 - 21072579
AN - SCOPUS:78751591728
SN - 0957-5243
VL - 22
SP - 73
EP - 79
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 1
ER -