Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa

Michèle R. Prinsep; Gregory M.L. Patterson; Linda K. Larsen; Charles D. Smith

doi:10.1021/np970566+

Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa

Michèle R. Prinsep, Gregory M.L. Patterson, Linda K. Larsen, Charles D. Smith

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Abstract

Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl₃.

Original language	English (US)
Pages (from-to)	1133-1136
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	9
DOIs	https://doi.org/10.1021/np970566+
State	Published - Sep 1998

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3.",

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AU - Prinsep, Michèle R.

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AU - Larsen, Linda K.

AU - Smith, Charles D.

PY - 1998/9

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AB - Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3.

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Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa

Abstract

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