TonB-dependent energy transduction between outer and cytoplasmic membranes

Kathleen Postle, Ray A. Larsen

Research output: Contribution to journalArticlepeer-review

139 Scopus citations


The TonB system of Escherichia coli (and most other Gram-negative bacteria) is distinguished by its importance to iron acquisition, its contribution to bacterial pathogenesis, and a unique and mysterious mechanism of action. This system somehow gathers the potential energy of the cytoplasmic membrane (CM) proton gradient and delivers it to active transporters in the outer membrane (OM). Our understanding of this system is confounded by the challenge of reconciling often contradictory in vivo and in vitro studies that are presented in this review.

Original languageEnglish (US)
Pages (from-to)453-465
Number of pages13
Issue number3-4
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Metals and Alloys


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