Topical intranasal fluorescein to localize a cerebrospinal fluid leak: a demonstration

Jeremy Barr, Jason Ni, Johnathan McGinn, Neerav Goyal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Intrathecal fluorescein is commonly used to localize cerebrospinal fluid leaks. This technique is invasive and associated with several potential adverse effects. The purpose of this video presentation is to demonstrate an alternative technique, the intranasal use of dilute topical fluorescein, to localize a cerebrospinal fluid leak intraoperatively. Methods: A 45-year-old male with a history of benign intracranial hypertension and 2 months of right-sided rhinorrhea underwent surgical repair of a cerebrospinal fluid leak. Topical fluorescein was applied intraoperatively to localize the defect. Results: At 1- and 3-month follow-ups the patient was without cerebrospinal fluid rhinorrhea and the middle turbinate flap was intact. Conclusion: Topical application of dilute intranasal fluorescein is a feasible and efficient tool for localizing cerebrospinal fluid leaks.

Original languageEnglish (US)
Article number102413
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number6
StatePublished - Nov 1 2020

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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