Topology, dynamics, and control in cortical blood flow elucidated with optical techniques

Philbert S. Tsai, Pablo Blinder, Patrick James Drew, Jonathan Driscoll, Diana Jeong, John P. Kaufhold, Andy Shih, Ilya Valmianski, David Kleinfeld

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Blood is a limited resource that supplies neurons and glia with nutriments. How is blood distributed both in a fail-safe way and in response to changing metabolic loads? We examine this issue in rodent cortex. First, in terms of topology, all-optical histology is used to reconstruct the vasculature network. Second, in terms of dynamics, the flux of blood cells in individual vessels is measured in response to neuronal activation and/or the perturbation of flow of a targeted vessel via plasma-mediated ablation. Lastly, in terms of control, optical indicators of neurovascular signaling molecules that alter vessel diameter are measured.

Original languageEnglish (US)
Title of host publicationBiosensing II
StatePublished - 2009
EventBiosensing II - San Diego, CA, United States
Duration: Aug 4 2009Aug 6 2009

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherBiosensing II
Country/TerritoryUnited States
CitySan Diego, CA

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Applied Mathematics
  • Electrical and Electronic Engineering
  • Computer Science Applications


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