Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Matthew L. Meketa; Steven M. Weinreb

doi:10.1021/ol0602304

Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Matthew L. Meketa
, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

Original language	English (US)
Pages (from-to)	1443-1446
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	7
DOIs	https://doi.org/10.1021/ol0602304
State	Published - Mar 30 2006

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0602304

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title = "Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai",

abstract = "A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.",

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AU - Weinreb, Steven M.

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N2 - A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

AB - A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.

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JO - Organic Letters

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Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

Abstract

All Science Journal Classification (ASJC) codes

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