Abstract
A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2- enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.
Original language | English (US) |
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Pages (from-to) | 12451-12453 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 133 |
Issue number | 32 |
DOIs | |
State | Published - Aug 17 2011 |
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry