Total synthesis of (±)-isophellibiline

Raymond L. Funk, Johannes Belmar

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The total synthesis of (±)-isophellibiline is described. This represents the first synthesis of a member of the nonaromatic homoerythrinan family of alkaloids. The tetracyclic ring system of the natural product was quickly assembled by a strategy that features a retrocycloaddition/cycloaddition reaction of amidodioxin, an intramolecular Heck reaction and a 6π-electrocyclic ring closure of a dienoic acid.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalTetrahedron Letters
Issue number2
StatePublished - Jan 11 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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