Total synthesis of pawhuskin C: A directed ortho metalation approach

Jeffrey D. Neighbors, Maya S. Salnikova, David F. Wiemer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The total synthesis of the opioid modulator pawhuskin C has been accomplished in eight steps from methyl 3,5-dihydroxybenzoate. The key step in this sequence is a directed ortho metalation reaction conducted without protection of a benzylic alcohol and thus presumed to involve a formal dianion intermediate.

Original languageEnglish (US)
Pages (from-to)1321-1324
Number of pages4
JournalTetrahedron Letters
Issue number8
StatePublished - Feb 21 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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