Abstract
Olivin (2) is the aglycon of the antitumor antibiotic olivomycin A (1). A total synthesis of 3, the trimethyl ether of olivin, has been successfully achieved by a convergent route. The key β-methoxyenone synthon 15 was prepared from 3,5-dimethoxyphenylacetic acid (4) and ketal ester 5. Condensation of 15 and methyl orsellinate dimethyl ether gave tricyclic ketone 17 which was subsequently elaborated into 3.
Original language | English (US) |
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Pages (from-to) | 1811-1812 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 106 |
Issue number | 6 |
DOIs | |
State | Published - Mar 1 1984 |
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry