Toward reliable multi-generational analysis of anatomical trees in 3D high-resolution CT images

K. C. Yu, E. L. Ritman, A. P. Kiraly, S. Y. Wan, M. Zamir, William Evan Higgins

Research output: Contribution to journalConference articlepeer-review

10 Scopus citations


Modern micro-CT and multidetector helical CT scanners can produce high-resolution 3D digital images of various anatomical tree structures, such as the coronary or hepatic vasculature and the airway tree. The sheer size and complexity of these trees make it essentially impossible to define them interactively. Automatic approaches, using techniques such as image segmentation, thinning, and centerline definition, have been proposed for a few specific problems. None of these approaches, however, can guarantee extracting geometrically accurate multigenerational tree structures. This limits their utility for detailed quantitative analysis of a tree. This paper proposes an approach for accurately defining 3D trees depicted in large 3D CT images. Our approach utilizes a three-stage analysis paradigm: (1) Apply an automated technique to make a "first cut" at defining the tree. (2) Analyze the automatically defined tree to identify possible errors. (3) Use a series of interactive tools to examine and correct each of the identified errors. At the end of this analysis, in principle, a more useful tree will be defined. Our paper will present a preliminary description of this paradigm and give some early results with 3D micro-CT images.

Original languageEnglish (US)
Pages (from-to)178-186
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Sep 22 2003

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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