Toxicological Profiling of Onion-Peel-Derived Mesoporous Carbon Nanospheres Using In Vivo Drosophila melanogaster Model

Vinay S. Bhat, Avinash Kundadka Kudva, Harshitha Venkatesh Naik, G. Reshmi, Shamprasad Varija Raghu, Paola De Padova, Gurumurthy Hegde

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3 Scopus citations


Toxicological profiling of the novel carbon materials has become imperative, owing to their wide applicability and potential health risks on exposure. In the current study, the toxicity of mesoporous carbon nanospheres synthesized from waste onion peel was investigated using the genetic animal model Drosophila melanogaster. The survival assays at different doses of carbon nanoparticles suggested their non-toxic effect for exposure for 25 days. Developmental and behavioral defects were not observed. The biochemical and metabolic parameters, such as total antioxidant capacity (TAC), protein level, triglyceride level, and glucose, were not significantly altered. The neurological toxicity as analyzed using acetylcholinesterase activity was also not altered significantly. Survival, behavior, and biochemical assays suggested that oral feeding of mesoporous carbon nanoparticles for 25 days did not elicit any significant toxicity effect in Drosophila melanogaster. Thus, mesoporous carbon nanoparticles synthesized from waste onion peel can be used as beneficial drug carriers in different disease models.

Original languageEnglish (US)
Article number1528
JournalApplied Sciences (Switzerland)
Issue number3
StatePublished - Feb 1 2022

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Instrumentation
  • General Engineering
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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