Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage

Laura Fernández-García, Sooyeon Song, Joy Kirigo, Michael E. Battisti, Maiken E. Petersen, María Tomás, Thomas K. Wood

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

IMPORTANCE: To date, there are no reports of phage infection-inducing persistence. Therefore, our results are important since we show for the first time that a phage-defense system, the MqsRAC toxin/antitoxin system, allows the host to survive infection by forming persister cells, rather than inducing cell suicide. Moreover, we demonstrate that the MqsRAC system works in concert with restriction/modification systems. These results imply that if phage therapy is to be successful, anti-persister compounds need to be administered along with phages.

Original languageEnglish (US)
Pages (from-to)e0338823
JournalMicrobiology Spectrum
Volume12
Issue number1
DOIs
StatePublished - Jan 11 2024

All Science Journal Classification (ASJC) codes

  • Physiology
  • Ecology
  • General Immunology and Microbiology
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

Cite this