TY - JOUR
T1 - Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage
AU - Fernández-García, Laura
AU - Song, Sooyeon
AU - Kirigo, Joy
AU - Battisti, Michael E.
AU - Petersen, Maiken E.
AU - Tomás, María
AU - Wood, Thomas K.
PY - 2024/1/11
Y1 - 2024/1/11
N2 - IMPORTANCE: To date, there are no reports of phage infection-inducing persistence. Therefore, our results are important since we show for the first time that a phage-defense system, the MqsRAC toxin/antitoxin system, allows the host to survive infection by forming persister cells, rather than inducing cell suicide. Moreover, we demonstrate that the MqsRAC system works in concert with restriction/modification systems. These results imply that if phage therapy is to be successful, anti-persister compounds need to be administered along with phages.
AB - IMPORTANCE: To date, there are no reports of phage infection-inducing persistence. Therefore, our results are important since we show for the first time that a phage-defense system, the MqsRAC toxin/antitoxin system, allows the host to survive infection by forming persister cells, rather than inducing cell suicide. Moreover, we demonstrate that the MqsRAC system works in concert with restriction/modification systems. These results imply that if phage therapy is to be successful, anti-persister compounds need to be administered along with phages.
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U2 - 10.1128/spectrum.03388-23
DO - 10.1128/spectrum.03388-23
M3 - Article
C2 - 38054715
AN - SCOPUS:85182501725
SN - 2165-0497
VL - 12
SP - e0338823
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 1
ER -
