Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants

J. R. Kaiser; C. H. Gauss; D. K. Williams

doi:10.1038/sj.jp.7211848

Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants

J. R. Kaiser, C. H. Gauss, D. K. Williams

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Objectives: Examining the effects of tracheal suctioning on cerebral hemodynamics of normotensive ventilated very low birth weight (VLBW) infants with normal cranial ultrasounds; determining the factor(s) influencing changes in mean cerebral blood flow velocity (CBFv) after suctioning. Methods: Seventy-three VLBW infants had continuous monitoring of mean arterial blood pressure (MABP), PaCO₂, PaO₂ and mean CBFv before, during, and after 202 suctioning sessions during the first week of life. Peak (or nadir) and relative changes of the four variables for 45min after suctioning were calculated. Multiple linear regression was used to determine the factor(s) influencing changes in mean CBFv after suctioning. Result: Birth weight was 928±244g; gestational age was 27.0±2.0 weeks. Mean CBFv increased to 31.0±26.4% after suctioning and remained elevated for 25min. PaCO₂ was highly associated with mean CBFv (P<0.001), whereas MABP and PaO₂ were not. Conclusion: We observed prolonged increases of mean CBFv following suctioning in ventilated VLBW infants that were previously unrecognized. This is concerning since disturbances of CBF may be associated with subsequent brain injury.

Original language	English (US)
Pages (from-to)	34-41
Number of pages	8
Journal	Journal of Perinatology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1038/sj.jp.7211848
State	Published - Jan 2008

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1038/sj.jp.7211848

Cite this

@article{adb0738e3e804c14843d70cf4a157ccf,

title = "Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants",

abstract = "Objectives: Examining the effects of tracheal suctioning on cerebral hemodynamics of normotensive ventilated very low birth weight (VLBW) infants with normal cranial ultrasounds; determining the factor(s) influencing changes in mean cerebral blood flow velocity (CBFv) after suctioning. Methods: Seventy-three VLBW infants had continuous monitoring of mean arterial blood pressure (MABP), PaCO2, PaO2 and mean CBFv before, during, and after 202 suctioning sessions during the first week of life. Peak (or nadir) and relative changes of the four variables for 45min after suctioning were calculated. Multiple linear regression was used to determine the factor(s) influencing changes in mean CBFv after suctioning. Result: Birth weight was 928±244g; gestational age was 27.0±2.0 weeks. Mean CBFv increased to 31.0±26.4% after suctioning and remained elevated for 25min. PaCO2 was highly associated with mean CBFv (P<0.001), whereas MABP and PaO2 were not. Conclusion: We observed prolonged increases of mean CBFv following suctioning in ventilated VLBW infants that were previously unrecognized. This is concerning since disturbances of CBF may be associated with subsequent brain injury.",

author = "Kaiser, {J. R.} and Gauss, {C. H.} and Williams, {D. K.}",

note = "Funding Information: The technical assistance of Natalie C Sikes and Melanie Mason, and the support of the University of Arkansas for Medical Sciences neonatologists, NICU nurses, respiratory therapists and ultrasound technicians, are gratefully acknowledged. JR Kaiser was supported by a National Institute of Neurological Disorders and Stroke Grant 1 K23 NS43185. The University of Arkansas for Medical Sciences, Center for Translational Neuroscience (RR20146) and General Clinical Research Center (M01RR14288) also supported this study. This study was presented, in part, at the 2006 Pediatric Academic Society, Society for Pediatric Research meeting, San Francisco, CA, April 29-May 2, 2006. There are no potential, perceived, or real conflicts of interest.",

year = "2008",

month = jan,

doi = "10.1038/sj.jp.7211848",

language = "English (US)",

volume = "28",

pages = "34--41",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants

AU - Kaiser, J. R.

AU - Gauss, C. H.

AU - Williams, D. K.

N1 - Funding Information: The technical assistance of Natalie C Sikes and Melanie Mason, and the support of the University of Arkansas for Medical Sciences neonatologists, NICU nurses, respiratory therapists and ultrasound technicians, are gratefully acknowledged. JR Kaiser was supported by a National Institute of Neurological Disorders and Stroke Grant 1 K23 NS43185. The University of Arkansas for Medical Sciences, Center for Translational Neuroscience (RR20146) and General Clinical Research Center (M01RR14288) also supported this study. This study was presented, in part, at the 2006 Pediatric Academic Society, Society for Pediatric Research meeting, San Francisco, CA, April 29-May 2, 2006. There are no potential, perceived, or real conflicts of interest.

PY - 2008/1

Y1 - 2008/1

N2 - Objectives: Examining the effects of tracheal suctioning on cerebral hemodynamics of normotensive ventilated very low birth weight (VLBW) infants with normal cranial ultrasounds; determining the factor(s) influencing changes in mean cerebral blood flow velocity (CBFv) after suctioning. Methods: Seventy-three VLBW infants had continuous monitoring of mean arterial blood pressure (MABP), PaCO2, PaO2 and mean CBFv before, during, and after 202 suctioning sessions during the first week of life. Peak (or nadir) and relative changes of the four variables for 45min after suctioning were calculated. Multiple linear regression was used to determine the factor(s) influencing changes in mean CBFv after suctioning. Result: Birth weight was 928±244g; gestational age was 27.0±2.0 weeks. Mean CBFv increased to 31.0±26.4% after suctioning and remained elevated for 25min. PaCO2 was highly associated with mean CBFv (P<0.001), whereas MABP and PaO2 were not. Conclusion: We observed prolonged increases of mean CBFv following suctioning in ventilated VLBW infants that were previously unrecognized. This is concerning since disturbances of CBF may be associated with subsequent brain injury.

AB - Objectives: Examining the effects of tracheal suctioning on cerebral hemodynamics of normotensive ventilated very low birth weight (VLBW) infants with normal cranial ultrasounds; determining the factor(s) influencing changes in mean cerebral blood flow velocity (CBFv) after suctioning. Methods: Seventy-three VLBW infants had continuous monitoring of mean arterial blood pressure (MABP), PaCO2, PaO2 and mean CBFv before, during, and after 202 suctioning sessions during the first week of life. Peak (or nadir) and relative changes of the four variables for 45min after suctioning were calculated. Multiple linear regression was used to determine the factor(s) influencing changes in mean CBFv after suctioning. Result: Birth weight was 928±244g; gestational age was 27.0±2.0 weeks. Mean CBFv increased to 31.0±26.4% after suctioning and remained elevated for 25min. PaCO2 was highly associated with mean CBFv (P<0.001), whereas MABP and PaO2 were not. Conclusion: We observed prolonged increases of mean CBFv following suctioning in ventilated VLBW infants that were previously unrecognized. This is concerning since disturbances of CBF may be associated with subsequent brain injury.

UR - http://www.scopus.com/inward/record.url?scp=38049005558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049005558&partnerID=8YFLogxK

U2 - 10.1038/sj.jp.7211848

DO - 10.1038/sj.jp.7211848

M3 - Article

C2 - 18165829

AN - SCOPUS:38049005558

SN - 0743-8346

VL - 28

SP - 34

EP - 41

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 1

ER -

Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this