Nonlinear ensemble state estimation offers a paradigm-shifting improvement in our ability to observe, predict, and control the state of spiking neuronal systems. We use an ensemble Kalman filter to predict hidden states and future trajectories in the Hodgkin-Huxley equations, reconstruct ion dynamics, control neuronal activity including a strategy for dynamic conductance clamping, and show the feasibility of controlling pathological cellular activity such as seizures.

Original languageEnglish (US)
Article number040901
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number4
StatePublished - Apr 1 2009

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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