Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins

Pamela J. Mitchell, Robert Tjian

Research output: Contribution to journalArticlepeer-review

2810 Scopus citations


The cloning of genes encoding mammalian DNA binding transcription factors for RNA polymerase II has provided the opportunity to analyze the structure and function of these proteins. This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors. The mechanisms by which these factors may activate transcriptional initiation and by which they may be regulated to achieve differential gene expression are also discussed.

Original languageEnglish (US)
Pages (from-to)371-378
Number of pages8
Issue number4916
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • General


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