Abstract
Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice through chemical toxins or can arise spontaneously from genetic mutations. Both models are associated with retinal vascular and neuronal changes. Retinal transcriptomic responses in C57BL/6J mice treated with streptozotocin and Ins2Akita/+ were compared after 3 months of hyperglycemia. Specific gene expression changes suggest a neurovascular inflammatory response in diabetic retinopathy. Genes common to the two models may represent theresponse of the retina to hyperglycemia, while changes unique to each model may represent time-dependent disease progression differences in the various models. Further investigation of the commonalities and differences between mouse models of type I diabetes may define cause and effect events in early diabetic retinopathy disease progression.
Original language | English (US) |
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Pages (from-to) | 202-213 |
Number of pages | 12 |
Journal | Journal of Ocular Biology, Diseases, and Informatics |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2009 |
All Science Journal Classification (ASJC) codes
- Ophthalmology
- Genetics