Transferrin expression in myelinated and non-myelinated peripheral nerves

Helen H. Lin, Brian S. Snyder, James Connor

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Transferrin and its receptor are involved in the delivery of iron to most cells. Previous studies have demonstrated that transferrin is associated with oligodendrocytes, the myelin-producing cells in the central nervous system. In the peripheral nervous system, the Schwann cell produces myelin. This study used immunohistochemistry and immunoblot analysis to determine whether expression of transferrin is unique to myelinated peripheral nerves. Immunohistochemical examination demonstrated cytoplasmic accumulation of transferrin in Schwann cells of the myelinated sciatic nerve, but not in the unmyelinated cervical sympathetic trunk. Immunoblot analysis revealed there is 10x the amount of transferrin in the sciatic nerve compared to the cervical sympathetic trunk. These results are consistent with the hypothesis that transferrin may play a role in myelination.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalBrain research
Issue number2
StatePublished - Sep 3 1990

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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