TY - CHAP
T1 - Transforming activities of JC virus early proteins
AU - Frisque, Richard J.
AU - Hofstetter, Catherine
AU - Tyagarajan, Shiva K.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - Polyomaviruses, as their name indicates, are viruses capable of inducing a variety of tumors in vivo. Members of this family, including the human JC and BK viruses (JCV, BKV), and the better characterized mouse polyomavirus and simian virus 40 (SV40), are small DNA viruses that commandeer a cell's molecular machinery to reproduce themselves. Studies of these virus-host interactions have greatly enhanced our understanding of a wide range of phenomena from cellular processes (e.g., DNA replication and transcription) to viral oncogenesis. The current chapter will focus upon the five known JCV early proteins and the contributions each makes to the oncogenic process (transformation) when expressed in cultured cells. Where appropriate, gaps in our understanding of JCV protein function will be supplanted with information obtained from the study of SV40 and BKV.
AB - Polyomaviruses, as their name indicates, are viruses capable of inducing a variety of tumors in vivo. Members of this family, including the human JC and BK viruses (JCV, BKV), and the better characterized mouse polyomavirus and simian virus 40 (SV40), are small DNA viruses that commandeer a cell's molecular machinery to reproduce themselves. Studies of these virus-host interactions have greatly enhanced our understanding of a wide range of phenomena from cellular processes (e.g., DNA replication and transcription) to viral oncogenesis. The current chapter will focus upon the five known JCV early proteins and the contributions each makes to the oncogenic process (transformation) when expressed in cultured cells. Where appropriate, gaps in our understanding of JCV protein function will be supplanted with information obtained from the study of SV40 and BKV.
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U2 - 10.1007/0-387-32957-9_21
DO - 10.1007/0-387-32957-9_21
M3 - Chapter
C2 - 16626044
AN - SCOPUS:33745590910
SN - 9780387292335
T3 - Advances in Experimental Medicine and Biology
SP - 288
EP - 309
BT - Polyomaviruses and Human Diseases
ER -