Transition metal-catalyzed C–H activation reactions: Diastereoselectivity and enantioselectivity

Ramesh Giri, Bing Feng Shi, Keary M. Engle, Nathan Maugel, Jin Quan Yu

Research output: Contribution to journalArticlepeer-review

1408 Scopus citations


This critical review discusses historical and contemporary research in the field of transition metal-catalyzed carbon–hydrogen (C–H) bond activation through the lens of stereoselectivity. Research concerning both diastereoselectivity and enantioselectivity in C–H activation processes is examined, and the application of concepts in this area for the development of novel carbon–carbon and carbon–heteroatom bond-forming reactions is described. Throughout this review, an emphasis is placed on reactions that are (or may soon become) relevant in the realm of organic synthesis (221 references).

Original languageEnglish (US)
Pages (from-to)3242-3272
Number of pages31
JournalChemical Society Reviews
Issue number11
StatePublished - Oct 22 2009

All Science Journal Classification (ASJC) codes

  • General Chemistry


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