Transition Metal-Catalyzed Dicarbofunctionalization of Unactivated Olefins

Roshan K. Dhungana, K. C. Shekhar, Prakash Basnet, Ramesh Giri

Research output: Contribution to journalReview articlepeer-review

322 Scopus citations


Transition metal (TM)-catalyzed difunctionalization of unactivated olefins with two carbon-based entities is a powerful method to construct complex molecular architectures rapidly from simple and readily available feedstock chemicals. While dicarbofunctionalization of unactivated olefins has a long history typically with the use of either carbon monoxide to intercept C(sp3)-[M] (alkyl-TM) species or substrates lacking in β-hydrogen (β-Hs), development of this class of reaction still remains seriously limited due to complications of β-H elimination arising from the in situ-generated C(sp3)-[M] intermediates. Over the years, different approaches have been harnessed to suppress β-H elimination, which have led to the development of various types of olefin dicarbofunctionalization reactions even in substrates that generate C(sp3)-[M] intermediates bearing β-Hs with a wide range of electrophiles and nucleophiles. In this review, these developments will be discussed both through the lens of historical perspectives as well as the strategies scrutinized over the years to address the issue of β-H elimination. However, this review article by no means is designed to be exhaustive in the field, and is merely presented to provide the readers an overview of the key reaction developments.

Original languageEnglish (US)
Pages (from-to)1314-1340
Number of pages27
JournalChemical Record
Issue number9
StatePublished - Sep 2018

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Materials Chemistry


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