Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A

A. M. Karinch; J. Floros

doi:10.1042/bj3070327

Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A

A. M. Karinch, J. Floros

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

Original language	English (US)
Pages (from-to)	327-330
Number of pages	4
Journal	Biochemical Journal
Volume	307
Issue number	2
DOIs	https://doi.org/10.1042/bj3070327
State	Published - 1995

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1042/bj3070327

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title = "Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A",

abstract = "Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.",

author = "Karinch, {A. M.} and J. Floros",

year = "1995",

doi = "10.1042/bj3070327",

language = "English (US)",

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journal = "Biochemical Journal",

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T1 - Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A

AU - Karinch, A. M.

AU - Floros, J.

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N2 - Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

AB - Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

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Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A

Abstract

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