Transmission of conformational change in insulin

Cyrus Chothia, Arthur M. Lesk, Guy G. Dodson, Dorothy C. Hodgkin

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


Crystal structures of insulin contain molecules that are similar but not identical in conformation. Packed helices move relative to each other, these shifts being accommodated by motions of side-chain atoms arising from small changes in torsion angles. Such low-energy conformational adjustments can accommodate shifts of no more than ∼1.5 . This limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
Issue number5908
StatePublished - 1983

All Science Journal Classification (ASJC) codes

  • General


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