Transmission of conformational change in insulin

Cyrus Chothia; Arthur M. Lesk; Guy G. Dodson; Dorothy C. Hodgkin

doi:10.1038/302500a0

Transmission of conformational change in insulin

Cyrus Chothia, Arthur M. Lesk, Guy G. Dodson, Dorothy C. Hodgkin

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Crystal structures of insulin contain molecules that are similar but not identical in conformation. Packed helices move relative to each other, these shifts being accommodated by motions of side-chain atoms arising from small changes in torsion angles. Such low-energy conformational adjustments can accommodate shifts of no more than ∼1.5 . This limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.

Original language	English (US)
Pages (from-to)	500-505
Number of pages	6
Journal	Nature
Volume	302
Issue number	5908
DOIs	https://doi.org/10.1038/302500a0
State	Published - 1983

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1038/302500a0

Cite this

@article{7b55afb9ac9e428d923903f4b9ba0455,

title = "Transmission of conformational change in insulin",

abstract = "Crystal structures of insulin contain molecules that are similar but not identical in conformation. Packed helices move relative to each other, these shifts being accommodated by motions of side-chain atoms arising from small changes in torsion angles. Such low-energy conformational adjustments can accommodate shifts of no more than ∼1.5 . This limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.",

author = "Cyrus Chothia and Lesk, \{Arthur M.\} and Dodson, \{Guy G.\} and Hodgkin, \{Dorothy C.\}",

year = "1983",

doi = "10.1038/302500a0",

language = "English (US)",

volume = "302",

pages = "500--505",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5908",

}

TY - JOUR

T1 - Transmission of conformational change in insulin

AU - Chothia, Cyrus

AU - Lesk, Arthur M.

AU - Dodson, Guy G.

AU - Hodgkin, Dorothy C.

PY - 1983

Y1 - 1983

N2 - Crystal structures of insulin contain molecules that are similar but not identical in conformation. Packed helices move relative to each other, these shifts being accommodated by motions of side-chain atoms arising from small changes in torsion angles. Such low-energy conformational adjustments can accommodate shifts of no more than ∼1.5 . This limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.

AB - Crystal structures of insulin contain molecules that are similar but not identical in conformation. Packed helices move relative to each other, these shifts being accommodated by motions of side-chain atoms arising from small changes in torsion angles. Such low-energy conformational adjustments can accommodate shifts of no more than ∼1.5 . This limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.

UR - https://www.scopus.com/pages/publications/0020614069

UR - https://www.scopus.com/inward/citedby.url?scp=0020614069&partnerID=8YFLogxK

U2 - 10.1038/302500a0

DO - 10.1038/302500a0

M3 - Article

C2 - 6339948

AN - SCOPUS:0020614069

SN - 0028-0836

VL - 302

SP - 500

EP - 505

JO - Nature

JF - Nature

IS - 5908

ER -

Transmission of conformational change in insulin

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this