Transmission of louping ill virus between infected and uninfected ticks co-feeding on mountain hares

Linda D. Jones; Michael Gaunt; Rosie S. Hails; Karen Laurenson; Peter J. Hudson; Hugh Reid; Pauline Henbest; Ernest A. Gould

doi:10.1111/j.1365-2915.1997.tb00309.x

Transmission of louping ill virus between infected and uninfected ticks co-feeding on mountain hares

Linda D. Jones, Michael Gaunt, Rosie S. Hails, Karen Laurenson, Peter J. Hudson, Hugh Reid, Pauline Henbest, Ernest A. Gould

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Most of the data on oral infection of ticks by louping ill virus have been obtained from experiments in which animals were infected by syringe inoculation with infectious material. Using infected ticks to mimic the natural situation, we have demonstrated that 1ouping ill (LI) virus transmission can occur from infected to uninfected Ixodes ricinus feeding in close proximity on mountain hares (Lepus timidus). Under these conditions the hares developed either low or undetectable viraemias. Highest prevalence of LI virus infection was observed in recipient nymphs which had fed to repletion between days 3 and 7 post-attachment of virus-infected adults; following engorgement, 56% of nymphs acquired virus. These results demonstrate the efficient transmission of LI virus between co-feeding ticks on naive mountain hares. However, when ticks were allowed to co-feed on virus-immune hares a significant reduction in the frequency of infection was observed. Neither red deer (Cervus elaphus) nor New Zealand White rabbits supported transmission of LI virus. The significance of virus transmission between cofeeding ticks on LI virus epidemiology is discussed.

Original language	English (US)
Pages (from-to)	172-176
Number of pages	5
Journal	Medical and Veterinary Entomology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2915.1997.tb00309.x
State	Published - Apr 1997

All Science Journal Classification (ASJC) codes

Parasitology
Ecology, Evolution, Behavior and Systematics
General Veterinary
Insect Science

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10.1111/j.1365-2915.1997.tb00309.x

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title = "Transmission of louping ill virus between infected and uninfected ticks co-feeding on mountain hares",

abstract = "Most of the data on oral infection of ticks by louping ill virus have been obtained from experiments in which animals were infected by syringe inoculation with infectious material. Using infected ticks to mimic the natural situation, we have demonstrated that 1ouping ill (LI) virus transmission can occur from infected to uninfected Ixodes ricinus feeding in close proximity on mountain hares (Lepus timidus). Under these conditions the hares developed either low or undetectable viraemias. Highest prevalence of LI virus infection was observed in recipient nymphs which had fed to repletion between days 3 and 7 post-attachment of virus-infected adults; following engorgement, 56% of nymphs acquired virus. These results demonstrate the efficient transmission of LI virus between co-feeding ticks on naive mountain hares. However, when ticks were allowed to co-feed on virus-immune hares a significant reduction in the frequency of infection was observed. Neither red deer (Cervus elaphus) nor New Zealand White rabbits supported transmission of LI virus. The significance of virus transmission between cofeeding ticks on LI virus epidemiology is discussed.",

author = "Jones, {Linda D.} and Michael Gaunt and Hails, {Rosie S.} and Karen Laurenson and Hudson, {Peter J.} and Hugh Reid and Pauline Henbest and Gould, {Ernest A.}",

year = "1997",

month = apr,

doi = "10.1111/j.1365-2915.1997.tb00309.x",

language = "English (US)",

volume = "11",

pages = "172--176",

journal = "Medical and Veterinary Entomology",

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T1 - Transmission of louping ill virus between infected and uninfected ticks co-feeding on mountain hares

AU - Jones, Linda D.

AU - Gaunt, Michael

AU - Hails, Rosie S.

AU - Laurenson, Karen

AU - Hudson, Peter J.

AU - Reid, Hugh

AU - Henbest, Pauline

AU - Gould, Ernest A.

PY - 1997/4

Y1 - 1997/4

N2 - Most of the data on oral infection of ticks by louping ill virus have been obtained from experiments in which animals were infected by syringe inoculation with infectious material. Using infected ticks to mimic the natural situation, we have demonstrated that 1ouping ill (LI) virus transmission can occur from infected to uninfected Ixodes ricinus feeding in close proximity on mountain hares (Lepus timidus). Under these conditions the hares developed either low or undetectable viraemias. Highest prevalence of LI virus infection was observed in recipient nymphs which had fed to repletion between days 3 and 7 post-attachment of virus-infected adults; following engorgement, 56% of nymphs acquired virus. These results demonstrate the efficient transmission of LI virus between co-feeding ticks on naive mountain hares. However, when ticks were allowed to co-feed on virus-immune hares a significant reduction in the frequency of infection was observed. Neither red deer (Cervus elaphus) nor New Zealand White rabbits supported transmission of LI virus. The significance of virus transmission between cofeeding ticks on LI virus epidemiology is discussed.

AB - Most of the data on oral infection of ticks by louping ill virus have been obtained from experiments in which animals were infected by syringe inoculation with infectious material. Using infected ticks to mimic the natural situation, we have demonstrated that 1ouping ill (LI) virus transmission can occur from infected to uninfected Ixodes ricinus feeding in close proximity on mountain hares (Lepus timidus). Under these conditions the hares developed either low or undetectable viraemias. Highest prevalence of LI virus infection was observed in recipient nymphs which had fed to repletion between days 3 and 7 post-attachment of virus-infected adults; following engorgement, 56% of nymphs acquired virus. These results demonstrate the efficient transmission of LI virus between co-feeding ticks on naive mountain hares. However, when ticks were allowed to co-feed on virus-immune hares a significant reduction in the frequency of infection was observed. Neither red deer (Cervus elaphus) nor New Zealand White rabbits supported transmission of LI virus. The significance of virus transmission between cofeeding ticks on LI virus epidemiology is discussed.

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Transmission of louping ill virus between infected and uninfected ticks co-feeding on mountain hares

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