Treatment of ADCY5 -Associated Dystonia, Chorea, and Hyperkinetic Disorders with Deep Brain Stimulation

Marisela E. Dy, Florence C.F. Chang, Sol De Jesus, Irina Anselm, Neil Mahant, Pamela Zeilman, Lance H. Rodan, Kelly D. Foote, Wen Hann Tan, Emad Eskandar, Nutan Sharma, Michael S. Okun, Victor S.C. Fung, Jeff L. Waugh

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


ADCY5 mutations have been reported as a cause of early onset hyperkinetic movements associated with delayed motor milestones, hypotonia, and exacerbation during sleep. The movement disorder may be continuous or episodic, and can vary considerably in severity within families and in individuals. The authors report a case series of 3 patients with ADCY5 mutations treated with deep brain stimulation after unsuccessful medication trials. All had extensive imaging, metabolic, and genetic testing prior to confirmation of their ADCY5 mutation. Two of the patients had the c.1252C>T; p.R418W mutation, while the youngest and most severely affected had a de novo c.2080-2088del; p.K694-M696 mutation. All had variable and incomplete, but positive responses to deep brain stimulation. The authors conclude that deep brain stimulation may provide benefit in ADCY5-related movement disorders. Long-term efficacy remains to be confirmed by longitudinal observation. ADCY5 should be considered in the differential diagnosis of early onset hyperkinetic movement disorders, and may respond to deep brain stimulation.

Original languageEnglish (US)
Pages (from-to)1027-1035
Number of pages9
JournalJournal of Child Neurology
Issue number8
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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