TY - GEN
T1 - Treatment status predicts differential prefrontal cortical responses to alcohol and natural reinforcer cues among alcohol dependent individuals
AU - Bunce, Scott
AU - Izzetoglu, Kurtulus
AU - Izzetoglu, Meltem
AU - Ayaz, Hasan
AU - Pourrezaei, Kambiz
AU - Onaral, Banu
PY - 2012/8/27
Y1 - 2012/8/27
N2 - This study used functional near-infrared spectroscopy (fNIRs) to test the hypothesis that non-treatment seeking alcohol-dependent participants (NTSA) would show greater response in dorsolateral prefrontal cortex (DLPFC) to alcohol cues than recovering alcoholics (RA; sober 90-180 days) or social drinkers. Opposite predictions were made for responses to natural reward cues. NTSA (n=4), RA (n=6), and social drinkers (n=4) were exposed to alcohol and natural reward cues while being monitored with fNIRs. Results confirmed enhanced responses to alcohol cues among NTSA vs. RA in right middle frontal gyrus. The opposite effect (RA>NTSA) was found in response to natural reward cues. Neural responses to alcohol and natural reward cues were negatively correlated in right DLPFC. Real-time craving ratings were positively correlated with greater neural response to alcohol cues. Differential responses to drug and natural reward cues suggest that a psychological mechanism related to treatment status may modulate drug cue responses in DLPFC.
AB - This study used functional near-infrared spectroscopy (fNIRs) to test the hypothesis that non-treatment seeking alcohol-dependent participants (NTSA) would show greater response in dorsolateral prefrontal cortex (DLPFC) to alcohol cues than recovering alcoholics (RA; sober 90-180 days) or social drinkers. Opposite predictions were made for responses to natural reward cues. NTSA (n=4), RA (n=6), and social drinkers (n=4) were exposed to alcohol and natural reward cues while being monitored with fNIRs. Results confirmed enhanced responses to alcohol cues among NTSA vs. RA in right middle frontal gyrus. The opposite effect (RA>NTSA) was found in response to natural reward cues. Neural responses to alcohol and natural reward cues were negatively correlated in right DLPFC. Real-time craving ratings were positively correlated with greater neural response to alcohol cues. Differential responses to drug and natural reward cues suggest that a psychological mechanism related to treatment status may modulate drug cue responses in DLPFC.
UR - http://www.scopus.com/inward/record.url?scp=84865232874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865232874&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-31561-9_20
DO - 10.1007/978-3-642-31561-9_20
M3 - Conference contribution
AN - SCOPUS:84865232874
SN - 9783642315602
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 183
EP - 191
BT - Advances in Brain Inspired Cognitive Systems - 5th International Conference, BICS 2012, Proceedings
T2 - 5th International Conference on Advances in Brain Inspired Cognitive Systems, BICS 2012
Y2 - 11 July 2012 through 14 July 2012
ER -